Diesel Exhaust Particles Stimulate Adaptive Immunity by Acting on Pulmonary Dendritic Cells

Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells.

Particulate matter, such as diesel exhaust particles (DEPs), modulate adaptive immune responses in the lung; however, their mechanism of action remains largely unclear. Pulmonary dendritic cells (DCs) are crucial mediators in regulating immune responses. We hypothesized that the immunomodulatory effects of DEPs are caused by alteration of DC function. To test this, we instilled mice with DEPs a...

Immunity by Acting on Pulmonary Dendritic Diesel Exhaust Particles Stimulate Adaptive

Eugenol attenuates pulmonary damage induced by diesel exhaust particles.

Environmentally relevant doses of inhaled diesel particles elicit pulmonary inflammation and impair lung mechanics. Eugenol, a methoxyphenol component of clove oil, presents in vitro and in vivo anti-inflammatory and antioxidant properties. Our aim was to examine a possible protective role of eugenol against lung injuries induced by diesel particles. Male BALB/c mice were divided into four grou...

Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). I. Effects of DEPs on early pulmonary responses.

It has been hypothesized that diesel exhaust particles (DEPs) aggravate pulmonary bacterial infection by both innate and cell-mediated immune mechanisms. To test this hypothesis, we investigated the effects of DEP exposure on the functions of alveolar macrophages (AMs) and lymphocytes from lung-draining lymph nodes using a rat Listeria monocytogenes infection model. In the present study, we foc...

Experimental Study on Diesel Exhaust Particles Agglomeration Using Acoustic Waves

Diesel exhaust particles are a complex mixture of thousands of gases and fine substances that contain more than 40 different environmental contaminants. Being exposed to these exhaust particles (called soot) can cause lung damage and respiratory problems. Diesel particulate filters are used in many countries for mobile sources as a legal obligation to decrease harmful effect of these fine pa...